CAD
The presence of coronary artery disease is obvious in patients, with an prior MI,
revascularization procedure, or a coronary angiogram that demonstrated luminal obstructions
or irregularities. However, patients may have multi-vessel CAD that is not clinically
aparent because the patients symptoms may be atypical or the patient may be functionally
limited by conditions such as COPD, arthritis or peripheral vascular disease.
However since current evidence suggests that coronary revascularization before noncardiac
surgery is of the limited value, only patients who are otherwise
candidates for revascularization independent of any planned surgery may stand to benefit
from noninvasive evaluation.
The clinical questions that need to be answered during the evaluation of patients
with known or suspected CAD include: 1) the extent of the myocardium in jeopardy;
2) the ischemic threshold or the amount of stress required to produce ischemia,
3) the patient’s ventricular function and; 4) whether the patient is receiving optimal medical therapy.
Current review of the literature suggests that PCI before noncardiac surgery is
of no value in preventing perioperative cardiac events, except in those patients
in whom PCI is independently indicated for an acute coronary syndrome.
there are reports of ACE inhibitors or angiotensin II receptor antagonists being
associated with perioperative hypotension and renal impairment.
- if the ACEI or ARB is stopped before surgey, it should be restarted when the patient
is euvolemic.
Arrhythmias and Conduction System Abnormalities
- preoperative arrhythmias should initiate an evaluation
for cardiopulmonary diseases, drug toxicity or metabolic derangements
- asymptomatic ventricular arrhythmias, including nonsustained
ventricular tachycardia is not associated with increased cardiac complications
after noncardiac surgery
- treatment of ventricular arrhthmias is warranted only
if symptoms arise or if it causes hemodynamic compromise
- electrophysiologic testing and catheter ablation may
be indicated to prevent recurrenct arrhythmias in patients with documented
hemodynamically significant or symptomatic arrhythmias
- acute treatment, including electrical or pharmacological
cardioversion, is indicated for hemodynamically significant or symptomatic arrhythmias
- in atrial fibrillation or atrial flutter, a rate control
strategy can be accomplished with beta-adrenergic blockers, calcium channel blockers,
or digoxin
- in patients with chronic or paroxysmal atrial fibrillation
before surgery, bridging anticoagulation,with either low-molecularweight or
unfractionated heparin, if the thromboembolic risk assessment warrants
- physicians should not hesitate to initiate prophylactic
beta-blocker therapy in patients at increased risk supraventricular or ventricular
tachyarrhythmias
- high-grade cardiac conduction abnormalities, i.e., complete atrioventricular block
can increase risk and may require temporary or permanent transvenous pacing
- intraventricular conduction delays, esuch as a left or right bundle-branch block,
and no history of advanced heart block or symptoms rarely progress to complete heart
block perioperatively
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CHF
- CHF is associated with poorer outcomes after noncardiac surgery.
- an effort must be made to detect unsuspected CHF by history and physical examination.
- it is also important to identify the cause of heart failure, as this may have beaqring
on the risk of death or perioperative heart bfailure.
- preoperative assessment of LV function may be recommended to quantify the
severity of systolic and diastolic dysfunction in .patients with a history or signs
of CHF.
- hypertrophic obstructive cardiomyopathy (HCM) poses special problems. These these
patients had a significant incidence of adverse cardiac events, frequently manifested
as HF.
- in HCM echocardiographic features are not associated with adverse cardiac events.
- Beta adrenergic agonists should be avoided as they can increase the degree of dynamic
obstruction and decrease diastolic filling..
Pacemakers and ICD
- in patients who are pacemaker dependen, the device should be reprogrammed to VOO
or DOO or a magnet should be placed over the device during surgery
- An ICD should have its tachyarrhythmia treatment algorithms programmed off and turned
on after surgery to prevent unwanted shocks
- during the time when device therapy has been inactivated, the patient should be
monitored continuously for a life-threatening arrhythmia
- minimize the chance of electromagnetic interference by: 1) use of a bipolar electrocautery,
2) the use of short and intermittent bursts of electrocautery at the lowest possible
energy levels, 3) maximizing the distance between the electrocautery and the device,
4) placement of the ground patch so as to minimize current flow through the device.
- if emergency cardioversion is required, the paddles should be placed as far from
the implanted device as possible and in an orientation likely to be perpendicular
to the orientation of the device leads (preferrably in the anterior-posterior position)
- if the pacemaker or ICD was reprogrammed before surgery, it should be programmed
back to its original settings after
Pulmonary Hypertension and Congenital Heart Disease
- There are no reported studies that specifically assess the perioperative
risk of patients with pulmonary vascular disease
- with severe pulmonary hypertension and a cardiac shunt, systemic hypotension results
in increased right-to-left shunting, leading to acidosis, which can lead to further
decreases in systemic vascular resistance
- in women with Eisenmenger syndrome due to a congenital intracardiac shunt, peripartum
mortality was reported to be between 30% and 70%; howevert no recent data exist
- patients with congenital heart disease have reduced cardiac reserve in response
to stress
- patients receiving primary cardiac repair at a young age may be less prone to postoperative
ventricular dysfunction
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Valvular Heart Disease
- severe aortic stenosis is associated with the greatest risk during noncardiac surgery.
- in symptomatic aortic stenosis, elective noncardiac surgery should generally be
postponed or canceled pending aortic valve replacement
- in asymptomatic severe aortic stenosis surgery should be deferred unless the valve
has been evaluated within the past year
- patients with severe aortic stenosis who refuse or are not candidates for
aortic valve replacement, noncardiac surgery is associated with a mortality
risk of approximately 10%
- percutaneous balloon aortic valvuloplasty may be a nreasonable bridge to surgery
in hemodynamically unstable patients or in patients whom aortic valve replacement
cannot be performed due to serious comorbid conditions
- in mild - moderate mitral stenosis, ensure heart rate control during the perioperative
period to avoid severe pulmonary congestion
- in severe mitral stenosis severe, patients may benefit from balloon mitral
valvuloplasty or open surgical repair before high-risk surgery
- for aortic regurgitation (AR), attention to volume control and afterload reduction
is recommended
- if AR is suspected, qualification of the severity is recommended to assist with
follow-up and guide therapy
- the 2 most common caus of mitral regurgitatgion are mitral valve prolapse that results
from myxomatous degeneration and functional mitral regurgitation
- patients with severe mitral regurgitation may benefit from afterload reduction
and administration of diuretics to produce maximal hemodynamic stabilization before
high-risk surgery
- in mitral regurgitation, a mild reduction of the LV ejection fraction (LVEF) may
be a sign of reduced ventricular reserve
- in patients with atrial fibrillation and at high risk for thromboembolism,
preoperative and postoperative therapy with intravenous heparin or subcutaneous
lowmolecular- weight heparin may be considered
- in patients with a mechanical prosthetic valve, review the need for endocarditis
prophylaxis
- for minimally invasive procedures (e.g. dental work, superficial biopsies), reduce
the international normalized ratio (INR) to the low or subtherapeutic range and
resume the normal dose of oral anticoagulation immediately after the procedure
- perioperative unfractionated heparin therapy is recommended for patients at high
risk of thromboembolism without anticoagulation .
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